Could Family History of Diabetes Impact Bone Health?

Even in ladies without diabetes, with no trouble having a circle of relatives history of diabetes could mean various things for health, according to a new study.
In a pattern of almost 900 postmenopausal women with normoglycemia, girls who had a first-degree relative with diabetes definitely had a considerably better bone mineral density (BMD) in the lumbar backbone in comparison with girls without a circle of relatives history (0.890 vs 0.85, P<0.05), Lijuan Yang, MD, of the First Affiliated Hospital of Wenzhou Medical University in China, and colleagues wrote in Menopause: The Journal of The North American Menopause Society.
These older ladies with a first-degree relative with diabetes also saw significantly increased BMD in the femoral neck, as well (1.077±0.146 vs 1.034±0.112, P<0.01).
However, both lumbar spine and femoral neck BMD were related with higher levels of insulin resistance among those girls, as measured through the Homeostasis Model Assessment-Insulin Resistance index (r=0.068 and0.094, respectively).

BMD turned into also absolutely tied to better expected glomerular filtration cost (r=0.227 for lumbar spine; r=0.159 for femoral neck).
Femoral neck (but not lumbar spine) BMD become also absolutely linked to higher body mass index (r=0.118) and triglycerides (r=0.026).
“This finding may be associated to higher insulin degrees in these ladies with a hereditary predisposition to diabetes, because insulin has a bone-building effect,” suggested Stephanie Faubion, MD, clinical director of the North American Menopause Society, in a statement.
Faubion, who became now not involved with the study, delivered that even though “this sounds like sensible news, these girls are at higher possibility for arising diabetes, which is associated with skeletal fragility and increased fracture risk.”
As expected, the researchers said, BMD values for the lumbar spine and femoral neck were negatively correlated with age (r=-0.307 and 0.197, respectively), as neatly as the number of years into menopause (r=-0.307 and -0.197, respectively).
BMD in either place changed into not correlated with hemoglobin A1c, cholesterol serum uric acid, or C-reactive protein degrees.
For the cross-sectional study, Yang’s neighborhood assessed Chinese ladies free of diabetes (average age 55), 147 of whom had a parent, sibling, or offspring with diabetes compared with 745 postmenopausal women without a first-degree family history of diabetes. The researchers gathered files on clinical features including frame weight and fasting blood samples, whilst BMD became measured with DXA scans.
Although outdated reports have already reported a link between classification 2 diabetes and BMD, the researchers pointed out that no previous experiences have suggested a link with familial diabetes history and bone health.
“The competencies mechanisms underlying the contribution of a first-degree FHD [family history of diabetes] to BMD remained to be determined,” Yang, et al. wrote. “Until now, there has been no direct evidence supporting the contribution of genetic factors to the alteration in BMD in americans with an FHD … Individuals with a first-degree FHD inherit susceptibility to insulin resistance, which may also extra lead to high BMD.”
The researchers also pointed out some obstacles to the look at, one of which was the assertion that the team did not verify osteocalcin, levels of procollagen type 1 N-terminal propeptide, or bone strength.
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Last Updated August 23, 2019
The study changed into funded by the National Key R&D Program of China and the Wenzhou Science & Technology Bureau.Yang and co-authors mentioned no conflicts of interest.